ACECLOFENAC LOADED SOLID LIPID NANOPARTICLES: OPTIMIZATION, IN VITRO AND EX-VIVO EVALUATION

Objective: Rheumatoid arthritis is treated with aceclofenac as the first line of treatment. Aceclofenac a BCS-II drug, when taken orally, causes first-pass metabolism and partially water-insoluble causing some gastrointestinal (GI) issues. Objective work was preparation evaluation solid lipid nanoparticle for rheumatoid increases drug permeability further possibility to decreasing irritation. Methods: Different formulations batches were prepared by soya lecithin, tween 20, bees wax cetyl alcohol using extrusion method. Further, selected batch proceeded Particle size, zeta potential, entrapment efficiency, in vitro release, Fourier transformed infrared (FTIR), X-ray diffraction studies (XRD), ex-vivo study goat skin. Results: As result, have nanometric 72.44% sustained released (71.33%) 6 h. The transformed-infrared (FT-IR) (XRD) confirm compatibility excipients. Ex-vivo permeation showed 74.85% permeate h through Conclusion: Research demonstrates that particle size effectiveness are significantly influenced level lecithin present. Additionally, it suitable treatment arthritis.